Early embryonic arrest denotes premature termination of development in pre-implantation
embryos, which is one of the major phenotypes of recurrent assisted reproduction failure …

Early embryonic arrest is one of the major causes of female infertility. However, because of
difficulties in phenotypic evaluation, genetic determinants of human early embryonic arrest …

Purpose To investigate the pathogenesis of the recurrent preimplantation embryonic arrest
characterized by direct cleavage. Methods Two affected individuals underwent time-lapse …

Background It has been proved that mutations in the PADI6 gene can cause early embryo
arrest. This study describes a newly discovered mutation in PADI6 that expands the genetic …

Peptidyl arginine deiminase, type VI (PADI6) is a member of the subcortical maternal
complex (SCMC), which plays vital roles in mammalian embryogenesis. Most mutations in …

The subcortical maternal complex (SCMC) is an oocyte‐to‐embryo‐specific maternal
functional module. Some variants of SCMC genes that contribute to preimplantation …

Successful human reproduction initiates from normal gamete formation, fertilization and
early embryonic development. Abnormalities in any of these steps will lead to infertility …

Purpose This study aims to identify genetic causes of female infertility associated with
recurrent failure of assisted reproductive technology (ART) characterized by embryonic …

Recurrent hydatidiform moles (RHM) are aberrant human pregnancies characterized by
absence of, or abnormal, embryonic development, hydropic degeneration of chorionic villi …

The subcortical maternal complex (SCMC), composed of several maternal‐effect genes, is
vital for the development of oocytes and early embryos. Variants of SCMC‐encoding genes …