Background Roux-en-Y gastric bypass (RYGB) is associated with a high rate of type 2
diabetes (T2D) remission. Carriers of heterozygous variants in the leptin-melanocortin …

Introduction Heterozygous variants in the leptin-melanocortin pathway are associated with
obesity. However, their effect on the long-term outcomes after Roux-en-Y gastric bypass …

The leptin-melanocortin pathway (LMP) is an essential component of hypothalamic energy
balance regulation. Heterozygous variants in genes encoding for components of the LMP …

Abstract Background Transoral outlet reduction (TORe) is a safe and effective technique for
management of weight regain (WR) after Roux-en-Y Gastric Bypass (RYGB). Carriers of a …

Objective The underlying causes of type 2 diabetes (T2DM) remain poorly understood.
Adipose tissue dysfunction with high leptin, inflammation, and increased oxidative stress …

Background & Aims Leptin, the protein product of the ob gene, increases energy
expenditure and reduces food intake, thereby promoting weight reduction. Leptin also …

Purpose The purpose of this study is to evaluate the relationship between body composition,
basal metabolic rate (BMR), and serum concentrations of leptin with long-term weight regain …

Background Roux-en-Y gastric bypass (RYGB) surgery is an effective metabolic surgery
against diabetes and obesity. Clinical evidence indicates that patients with severe obesity …

Sensitization to the adipokine leptin is a promising therapeutic strategy against obesity and
its comorbidities and has been proposed to contribute to the lasting metabolic benefits of …

Objective The objective of this meta‐analysis was to quantify the overall effects of gene
mutations in the leptin‐melanocortin pathway on short‐and long‐term weight loss after …