Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis
G Cholewiński, K Dzierzbicka, AM Kołodziejczyk - Pharmacological reports, 2011 - Elsevier
Acridine derivatives constitute a class of compounds that are being intensively studied as
potential anticancer drugs. Acridines are well-known for their high cytotoxic activity; …
potential anticancer drugs. Acridines are well-known for their high cytotoxic activity; …
Acridine and acridone derivatives, anticancer properties and synthetic methods: where are we now?
P Belmont, J Bosson, T Godet… - Anti-Cancer Agents in …, 2007 - ingentaconnect.com
Acridine derivatives are interesting chemotherapeutic agents that were first used as
antibacterial and antiparasite agents. In this review we wish to concentrate our attention on …
antibacterial and antiparasite agents. In this review we wish to concentrate our attention on …
Acridine and its derivatives: a patent review (2009–2013)
B Zhang, X Li, B Li, C Gao, Y Jiang - Expert opinion on therapeutic …, 2014 - Taylor & Francis
Introduction: Acridine derivatives have been extensively explored as potential therapeutic
agents for the treatment of a number of diseases, such as cancer, Alzheimer's, and bacterial …
agents for the treatment of a number of diseases, such as cancer, Alzheimer's, and bacterial …
Acridine derivatives as chemotherapeutic agents
WA Denny - Current Medicinal Chemistry, 2002 - ingentaconnect.com
Acridine derivatives are one of the oldest classes of bioactives, widely used as antibacterial
and antiprotozoal agents. Some work in these areas continues, but recent research has …
and antiprotozoal agents. Some work in these areas continues, but recent research has …
Niche for acridine derivatives in anticancer therapy
During the last 4 decades, intensive research has focussed on the effect of small organic
molecules with antitumour activity that are able to intercalate into DNA and inhibit …
molecules with antitumour activity that are able to intercalate into DNA and inhibit …
A comprehensive review on acridone based derivatives as future anti-cancer agents and their structure activity relationships
The development of drug resistance and severe side-effects has reduced the clinical efficacy
of the existing anti-cancer drugs available in the market. Thus, there is always a constant …
of the existing anti-cancer drugs available in the market. Thus, there is always a constant …
[HTML][HTML] Recent developments in the synthesis and biological activity of acridine/acridone analogues
M Gensicka-Kowalewska, G Cholewiński… - RSC …, 2017 - pubs.rsc.org
Many people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and
other diseases. Therefore, many scientists seek new, more effective, more selective and less …
other diseases. Therefore, many scientists seek new, more effective, more selective and less …
Acridine/acridone: a simple scaffold with a wide range of application in oncology
P Belmont, I Dorange - Expert Opinion on Therapeutic Patents, 2008 - Taylor & Francis
Background: The acridine scaffold is of interest since its DNA affinity and intercalative
properties make it an important pharmacophore for the design of antitumor drugs targeting …
properties make it an important pharmacophore for the design of antitumor drugs targeting …
[HTML][HTML] Acridine as an anti-tumour agent: a critical review
P Varakumar, K Rajagopal, B Aparna, K Raman… - Molecules, 2022 - mdpi.com
This review summarized the current breakthroughs in the chemistry of acridines as anti-
cancer agents, including new structural and biologically active acridine attributes. Acridine …
cancer agents, including new structural and biologically active acridine attributes. Acridine …
Acridine‐1, 8‐diones: Synthesis and Biological Applications
The unpretentious features of acridine‐1, 8‐diones viz. presence of N‐heteroatom,
electronic behavior, acridine ring skeleton and wide possibilities of diversified substitution …
electronic behavior, acridine ring skeleton and wide possibilities of diversified substitution …