Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis

G Cholewiński, K Dzierzbicka, AM Kołodziejczyk - Pharmacological reports, 2011 - Elsevier
Acridine derivatives constitute a class of compounds that are being intensively studied as
potential anticancer drugs. Acridines are well-known for their high cytotoxic activity; …

Acridine and acridone derivatives, anticancer properties and synthetic methods: where are we now?

P Belmont, J Bosson, T Godet… - Anti-Cancer Agents in …, 2007 - ingentaconnect.com
Acridine derivatives are interesting chemotherapeutic agents that were first used as
antibacterial and antiparasite agents. In this review we wish to concentrate our attention on …

Acridine and its derivatives: a patent review (2009–2013)

B Zhang, X Li, B Li, C Gao, Y Jiang - Expert opinion on therapeutic …, 2014 - Taylor & Francis
Introduction: Acridine derivatives have been extensively explored as potential therapeutic
agents for the treatment of a number of diseases, such as cancer, Alzheimer's, and bacterial …

Acridine derivatives as chemotherapeutic agents

WA Denny - Current Medicinal Chemistry, 2002 - ingentaconnect.com
Acridine derivatives are one of the oldest classes of bioactives, widely used as antibacterial
and antiprotozoal agents. Some work in these areas continues, but recent research has …

Niche for acridine derivatives in anticancer therapy

MR Galdino-Pitta, MGR Pitta, MCA Lima… - Mini Rev Med …, 2013 - ingentaconnect.com
During the last 4 decades, intensive research has focussed on the effect of small organic
molecules with antitumour activity that are able to intercalate into DNA and inhibit …

A comprehensive review on acridone based derivatives as future anti-cancer agents and their structure activity relationships

TT Yadav, M Murahari, GJ Peters, YC Mayur - European journal of …, 2022 - Elsevier
The development of drug resistance and severe side-effects has reduced the clinical efficacy
of the existing anti-cancer drugs available in the market. Thus, there is always a constant …

[HTML][HTML] Recent developments in the synthesis and biological activity of acridine/acridone analogues

M Gensicka-Kowalewska, G Cholewiński… - RSC …, 2017 - pubs.rsc.org
Many people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and
other diseases. Therefore, many scientists seek new, more effective, more selective and less …

Acridine/acridone: a simple scaffold with a wide range of application in oncology

P Belmont, I Dorange - Expert Opinion on Therapeutic Patents, 2008 - Taylor & Francis
Background: The acridine scaffold is of interest since its DNA affinity and intercalative
properties make it an important pharmacophore for the design of antitumor drugs targeting …

[HTML][HTML] Acridine as an anti-tumour agent: a critical review

P Varakumar, K Rajagopal, B Aparna, K Raman… - Molecules, 2022 - mdpi.com
This review summarized the current breakthroughs in the chemistry of acridines as anti-
cancer agents, including new structural and biologically active acridine attributes. Acridine …

Acridine‐1, 8‐diones: Synthesis and Biological Applications

N Sahiba, A Sethiya, J Soni, S Agarwal - ChemistrySelect, 2021 - Wiley Online Library
The unpretentious features of acridine‐1, 8‐diones viz. presence of N‐heteroatom,
electronic behavior, acridine ring skeleton and wide possibilities of diversified substitution …