Ovarian cancer is an aggressive disease that affects about 300,000 patients worldwide, with
a yearly death count of about 185,000. Following surgery, treatment involves adjuvant or …

Ovarian cancer has been nicknamed the “silent killer”. Most patients with ovarian cancer are
diagnosed at an advanced stage of the disease for the first time because of its insignificant …

One of the mechanisms of cisplatin cell cytotoxicity is the mitochondria-associated induction
of apoptosis. The morphological or functional change of mitochondria in cisplatin-resistant …

Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent
recurrence of resistance phenomena, it still remains the only therapeutic option for several …

The way cancer cells escape cisplatin-induced apoptosis has not been completely
elucidated yet. We questioned the relevance of “metabolic reprogramming” in cisplatin …

Patients with high-grade serous ovarian cancer (HGSC) frequently receive platinum-based
chemotherapeutics, such as cisplatin. Cisplatin binds to DNA and induces DNA-damage …

Doxorubicin is a widely used chemotherapeutic agent for the treatment of a variety of solid
tumors. However, resistance to this anticancer drug is a major obstacle to the effective …

Chemoresistance enables cancer cells to evade apoptotic stimuli and leads to poor clinical
prognosis. It arises from dysregulation of signaling factors responsible for inducing cell …

Ovarian cancer is the leading cause of death from gynecologic malignancy in the Western
world. This is due, in part, to the fact that despite standard treatment of surgery and …

Ovarian cancer is the major cause of death out of all the gynecologic cancers. The prognosis
of this cancer is quite poor since patients only seek treatment when it is at an advanced …