Phase 1 trial of Bi-shRNA STMN1 BIV in refractory cancer
M Barve, Z Wang, P Kumar, CM Jay, X Luo, C Bedell… - Molecular Therapy, 2015 - cell.com
Stathmin1 (STMN1) is a microtubule modulator that is expressed in multiple cancers and
correlates with poor survival. We previously demonstrated in vivo safety of bifunctional (bi) …
correlates with poor survival. We previously demonstrated in vivo safety of bifunctional (bi) …
Preclinical biodistribution and safety evaluation of a pbi-shRNA STMN1 lipoplex after subcutaneous delivery
Z Wang, CM Jay, C Evans, P Kumar… - Toxicological …, 2017 - academic.oup.com
Stathmin-1 (STMN1) is a microtubule-destabilizing protein which is overexpressed in
cancer. Its overexpression is associated with poor prognosis and also serves as a predictive …
cancer. Its overexpression is associated with poor prognosis and also serves as a predictive …
In vivo Safety and Antitumor Efficacy of Bifunctional Small Hairpin RNAs Specific for the Human Stathmin 1 Oncoprotein
AP Phadke, CM Jay, Z Wang, S Chen, S Liu… - DNA and cell …, 2011 - liebertpub.com
Bifunctional small hairpin RNAs (bi-shRNAs) are functional miRNA/siRNA composites that
are optimized for posttranscriptional gene silencing through concurrent mRNA cleavage …
are optimized for posttranscriptional gene silencing through concurrent mRNA cleavage …
Anti-STMN1 therapy improves sensitivity to antimicrotubule drugs in esophageal squamous cell carcinoma
S Wang, J Akhtar, Z Wang - Tumor Biology, 2015 - Springer
Stathmin (STMN1) regulates microtubule dynamics by promoting depolymerization of
microtubules and/or preventing polymerization of tubulin heterodimers. Several studies have …
microtubules and/or preventing polymerization of tubulin heterodimers. Several studies have …
RNAi targeting STMN alleviates the resistance to taxol and collectively contributes to down regulate the malignancy of NSCLC cells in vitro and in vivo
D Long, T Yu, X Chen, Y Liao, X Lin - Cell Biology and Toxicology, 2018 - Springer
Stathmin (STMN) plays a vital role in maintaining the malignant behavior of cancer through
directly regulating microtubule dynamics equilibrium. Taxol, an effective chemotherapeutics …
directly regulating microtubule dynamics equilibrium. Taxol, an effective chemotherapeutics …
Enhanced target gene knockdown by a bifunctional shRNA: a novel approach of RNA interference
DD Rao, PB Maples, N Senzer, P Kumar, Z Wang… - Cancer gene …, 2010 - nature.com
RNA interference (RNAi) is a natural cellular regulatory process that inhibits gene
expression by transcriptional, post-transcriptional and translational mechanisms. Synthetic …
expression by transcriptional, post-transcriptional and translational mechanisms. Synthetic …
Effectiveness of local injection of lentivirus‐delivered stathmin1 and stathmin1 shRNA in human gastric cancer xenograft mouse
J Akhtar, Z Wang, C Yu… - … of Gastroenterology and …, 2014 - Wiley Online Library
Abstract Background and Aim We have reported previously that RNA interference targeting
stathmin1 (STMN1) gene in human gastric cancer cells inhibits proliferation in vitro and …
stathmin1 (STMN1) gene in human gastric cancer cells inhibits proliferation in vitro and …
Stathmin 1: a novel therapeutic target for anticancer activity
S Rana, PB Maples, N Senzer… - Expert review of …, 2008 - Taylor & Francis
Stathmin 1 (STMN1), also known as p17, p18, p19, 19K, metablastin, oncoprotein 18, LAP
18 and Op18, is a 19 kDa cytosolic protein. It was the first discovered member of a family of …
18 and Op18, is a 19 kDa cytosolic protein. It was the first discovered member of a family of …
The knockdown of stathmin with si-RNA inhibits invasion of mesothelioma
A Aksoy, A Varoglu, EE Onalan, A Tektemur, G Artas… - Tissue and Cell, 2024 - Elsevier
Background To investigate the mechanism of action of stathmin1 (STMN1) in mesothelioma
(MSM) and whether it has any role in its treatment. Methods STMN1 expression was …
(MSM) and whether it has any role in its treatment. Methods STMN1 expression was …
Stathmin 1: a protein with many tasks. New biomarker and potential target in cancer
J Nemunaitis - Expert Opinion on Therapeutic Targets, 2012 - Taylor & Francis
Full article: Stathmin 1: a protein with many tasks. New biomarker and potential target in
cancer Skip to Main Content Taylor and Francis Online homepage Taylor and Francis Online …
cancer Skip to Main Content Taylor and Francis Online homepage Taylor and Francis Online …