Upregulation of lipogenesis is a hallmark of cancer and blocking the lipogenic pathway is
known to cause tumor cell death by apoptosis. However, the exact role of lipogenesis in …

Aberrant lipid metabolism has recently been recognized as a new hallmark of malignancy,
but the characteristics of fatty acid metabolism in breast cancer stem cells (BCSC) and …

In recent years, lipid metabolism has gained greater attention in several diseases including
cancer. Dysregulation of fatty acid metabolism is a key component in breast cancer …

The correction of specific signaling defects can reverse the oncogenic phenotype of tumor
cells by acting in a dominant manner over the cancer genome. Unfortunately, there have …

In normal tissues, energy-providing lipids come principally from circulating lipids. However,
in growing tumors, energy supply is mainly provided by lipids coming from de novo …

Aberrant activation of fatty acid synthesis is a key feature of many advanced human cancers.
Unlike in classical lipogenic tissues, this process has been implicated in membrane …

Increasing evidence reveal that breast cancer stem cells (BCSCs) subtypes with distinct
properties are regulated by their abnormal metabolic changes, however, the specific …

Abstract Background Cancer-associated fibroblasts (CAFs) coordinate the malignancy of
cancer cells via secretory materials. Reprogrammed lipid metabolism and signaling play …

Lipase member H (LIPH), a novel member of the triglyceride lipase family. The clinical
implications of its expression in breast cancer are still unclear. Therefore, in this study, we …

In breast cancer, lipid metabolic alterations have been recognized as potential oncogenic
stimuli that may promote malignancy. To investigate whether the oncogenic nature of …