Since the 1980s, the development of a pharmacology based on nerve growth factor (NGF)
has been postulated for the therapy of Alzheimer's disease (AD). This hypothesis was based …

Traumatic brain injury is one of the main causes of mortality and disability worldwide.
Traumatic brain injury is characterized by a primary injury directly induced by the impact …

The neurotrophin Nerve Growth Factor (NGF) holds a great potential as a therapeutic
candidate for the treatment of neurological diseases. However, its safe and effective delivery …

Purpose: To assess the potential of delivering nerve growth factor (NGF) to the brain along
the olfactory neural pathway for the treatment of Alzheimer's disease. Methods …

Neurotrophic factors (NTFs) are endogenous polypeptides that regulate the growth, survival,
differentiation, and functioning of neurons. The neuroprotective effects of NTFs in …

Background: Nerve growth factor (NGF) is known for playing a critical protective role on a
number of brain neurons in mammals, including humans. NGF can be delivered to the CNS …

The purpose of this work was to investigate whether, by intranasal administration, the nerve
growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if …

Background and Purpose Traumatic brain injury (TBI) comprises a primary injury directly
induced by impact, which progresses into a secondary injury leading to neuroinflammation …

Age-dependent progressive neurodegeneration and associated cognitive dysfunction
represent a serious concern worldwide. Currently, dementia accounts for the fifth highest …

Nerve growth factor (NGF) has been proved with the potential of promoting neurogenesis in
adult mammalians. This study was aimed to investigate the effect of intranasal (IN) NGF on …