Polyamines are thought to play an essential role in cellular hypertrophy and proliferation.
Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in …

Ornithine decarboxylase (ODC, EC 4.1. 1.7), a rate-limiting enzyme in polyamine
biosynthesis, is known to be induced by a beta-adrenoceptor agonist, isoproterenol (ISO) …

DFMO is a selective irreversible inhibitor of ornithine decarboxylase (ODC), the initial
enzyme in the polyamine biosynthetic pathway. DFMO was utilized to determine the role of …

Isoprenaline stimulated increases in ornithine decarboxylase activity and polyamine content
in cardiac tissues are implicated in macromolecular synthesis and cellular growth, but little is …

Ornithine decarboxylase, a possible rate-limiting enzyme in the synthesis of polyamines,
was assayed in hearts of normal rats, sham-operated rats, and rats subjected to aortic …

The role that the induction of cardiac ornithine decarboxylase (ODC), a key enzyme in
polyamine biosynthesis, by beta‐adrenergic agents may have in heart hypertrophy is a …

Ornithine decarboxylase (ODC), the first enzyme of polyamine metabolism, is rapidly
upregulated in response to agents that induce a pathological cardiac hypertrophy …

In this study, omithine decarboxylase, the first and rate-limiting enzyme of the polyamine
pathway, was used as a marker of the very early stages of cardiac hypertrophy. Our data …

To evaluate the role of polyamine biosynthesis in myocardial growth, the activity of ornithine
decarboxylase (ODC) and the levels of the polyamines, spermidine, spermine, and …

Two lines of transgenic mice were produced with constitutive expression of antizyme-1 in the
heart, driven from the cardiac α-myosin heavy chain promoter. The use of engineered …