Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …

Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United
States, with the number of affected people increasing. There are many risk factors that …

In this review, we discuss the application of mouse models to the identification and pre‐
clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early …

Colorectal cancer is a heterogeneous disease that afflicts a large number of people in the
USA. The use of animal models has the potential to increase our understanding of …

Colorectal cancer (CRC), despite the advances in screening and surveillance, remains the
second most common cause of cancer death worldwide. The biological inadequacy of pre …

Purpose: Patient-derived xenograft models are considered to represent the heterogeneity of
human cancers and advanced preclinical models. Our consortium joins efforts to extensively …

Existing preclinical models of human colorectal cancer (CRC) that rely on syngeneic
subcutaneous grafts are problematic, because of increasing evidence that the immune …

The study of experimental colon carcinogenesis in rodents has a long history, dating back
almost 80 years. There are many advantages to studying the pathogenesis of carcinogen …

Modelling human colon cancer has long been the ambition of researchers and oncologists
with the aim to better replicate disease progression and treatment response. Advances in …

Colorectal cancer (CRC) is one of the most common malignancies in the western world. Its
high mortality rates are particularly related to the occurrence of liver metastases. Many …