Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line

M Shizu, Y Itoh, R Sunahara, S Chujo… - Journal of Interferon & …, 2007 - liebertpub.com
Rheumatoid arthritis (RA) is characterized by proliferation of synoviocytes that produce
proinflammatory cytokines, which are implicated in the pathogenesis of RA. When human …

Cigarette smoke condensate extracts induce IL-1-beta production from rheumatoid arthritis patient-derived synoviocytes, but not osteoarthritis patient-derived …

M Adachi, S Okamoto, S Chujyo, T Arakawa… - Journal of Interferon & …, 2013 - liebertpub.com
Cigarette smoking is a major established environmental risk factor for rheumatoid arthritis
(RA), and synoviocyte-derived proinflammatory cytokines are implicated in the pathogenesis …

Cigarette smoke condensate extracts augment collagen-induced arthritis in mice

S Chujo, S Okamoto, R Sunahara, M Adachi… - International …, 2010 - Elsevier
Although cigarette smoking is a solid environmental risk factor for rheumatoid arthritis (RA)
as revealed by epidemiological studies, the scientific basis has not been provided …

Immunomodulatory effects of cigarette smoke condensate in mouse macrophage cell line

J Zhao, X Li, F Xie, Z Yang, X Pan… - International …, 2017 - journals.sagepub.com
Increasing evidence has demonstrated that the secretion of cytokines may be associated
with cigarette smoke–induced immunomodulatory effects, but a comprehensive analysis of …

[PDF][PDF] Increased pro-inflammatory activity and impairment of human monocyte differentiation induced by in vitro exposure to cigarette smoke

L Lerner, D Weiner, R Katz, AZ Reznick… - J Physiol …, 2009 - jpp.krakow.pl
Cigarette smoking (CS) is associated with a variety of human pathologies including
cardiovascular disease and cancer. Human monocytes are prevalent in oral and respiratory …

Kinetic analysis of cytokine response to cigarette smoke condensate by human endothelial and monocytic cells

BK Nordskog, WR Fields, GM Hellmann - Toxicology, 2005 - Elsevier
Atherosclerosis is generally considered an inflammatory disease characterized by the
accumulation of lipid in large and medium elastic arteries. Individuals who smoke are at …

Intracellular and extracellular cytokines in A549 cells and THP1 cells exposed to cigarette smoke

A Holownia, P Wielgat, E Rysiak, JJ Braszko - Respiratory Medicine and …, 2016 - Springer
Cigarette smoke (CS) activates inflammatory cells and increases cytokine levels producing
local and systemic inflammation. To assess changes in intracellular and extracellular …

Cigarette smoke condensate enhances respiratory syncytial virus–induced chemokine release by modulating NF-kappa B and interferon regulatory factor activation

SM Castro, D Kolli, A Guerrero-Plata… - Toxicological …, 2008 - academic.oup.com
Exposure to cigarette smoke is a risk factor contributing to the severity of respiratory tract
infections associated with respiratory syncytial virus (RSV). Stimulation of airway epithelial …

Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial …

M Laan, S Bozinovski, GP Anderson - The Journal of Immunology, 2004 - journals.aai.org
Chronic smoking is characterized by immunosuppressive changes in the airways, leading to
chronic colonization with bacteria, which in turn may contribute to the chronic obstructive …

Etiological and biological aspects of cigarette smoking in rheumatoid arthritis

K Onozaki - Inflammation & Allergy-Drug Targets (Formerly …, 2009 - ingentaconnect.com
Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by the chronic
inflammation of the synovium, which develops to joint destruction. Quite interestingly RA has …