Huntington's Disease (HD) is an inherited neurological disorder causing movement
impairment, personality changes, dementia, and premature death, for which there is …

Minocycline is an antibiotic with anti-inflammatory and antiapoptotic properties that prolongs
survival in a transgenic Huntington disease (HD) mouse model. In a double-blind …

Despite advances in understanding the pathogenesis of Huntington's disease (HD), there is
no effective treatment. In the HD transgenic mouse, expression of a dominant-negative …

Minocycline has been shown to be neuroprotective in various models of neurodegenerative
diseases. However, its potential in Huntington's disease (HD) models characterized by …

Abstract Huntington's disease (HD), a relentlessly progressive neurodegenerative disorder,
is characterized by a clinical triad of psychiatric, cognitive and motor disturbances. The …

The capacity of minocycline to alleviate disease for several neurological disorders in
animals is increasingly being recognised. Indeed, that one drug alone can attenuate the …

Huntington's disease (HD) is a devastating autosomal dominant disorder characterized by
progressive motor and neuropsychological symptoms. Evidence implicating the apoptotic …

Minocycline is a caspase inhibitor, decreases inducible nitric oxide synthase (iNOS), and
has been shown to delay disease progression in the mouse model R6/2 of Huntington's …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, which is
caused by an abnormal expansion of Cytosine Adenine Guanine (CAG) trinucleotide repeat …

Minocycline has been shown to exert anti‐inflammatory effects underlying its putative
neuroprotective properties in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP) …