Background: Burn injury causes nociceptive behaviors, and inflammation-related pathologic
pain can lead to glial cell activation. This study tested the hypothesis that burn injury …

Background Cannabinoid receptor agonists inhibit inflammatory hyperalgesia in animal
models. Nonselective cannabinoid receptor agonists also produce central nervous system …

Background Nerve growth factor (NGF) is central to processes involved in an inflammatory
hyperalgesia. Administration of exogenous NGF induces a hyperalgesia that is dependent …

Accumulating evidence suggests that cannabinoids can produce antinociception through
peripheral mechanisms. In the present study, we determined whether cannabinoids …

Background Cannabinoids bind to cannabinoid receptors type 1 and 2 and produce
analgesia in several pain models, but central side effects from cannabinoid 1 receptors limit …

Central antinociceptive effects of cannabinoids have been well documented. However,
relatively little is known about the peripheral effects of the cannabinoids on inflammation. In …

Background and Objectives Cannabinoid receptors (CB1R/CB2R) are known to play
important roles in pain transmission. In this study, we investigated the effects of continuous …

Background and purpose: Activation of cannabinoid (CB) receptors decreases nociceptive
transmission in inflammatory or neuropathic pain states. However, the effects of CB receptor …

BACKGROUND: Cannabinoid receptor 2 (CB 2) agonists have recently gained attention as
potential therapeutic targets in the management of neuropathic pain. In this study, we …

Background Cannabinoids induce analgesia by acting on cannabinoid receptor (CBR) types
1 and/or 2. However, central nervous system side effects and antinociceptive tolerance from …