Tumor initiation and progression are critically dependent on interaction of cancer cells with
their cellular and extracellular microenvironment. Alterations in the composition, integrity …

Extracellular matrix (ECM) is an essential and dynamic component of all tissues and directly
affects cellular behavior by providing both mechanical and biochemical signaling cues …

The tumor microenvironment (TME) is influenced by a" disorganized" extracellular matrix
(ECM) that sensitizes cancer cells toward mechanical stress, signaling, and structural …

Increased extracellular matrix (ECM) stiffness has been implicated in esophageal
adenocarcinoma (EAC) progression, metastasis, and resistance to therapy. However, the …

Extracellular matrix (ECM) structure, composition, and stiffness have profound effects on
tissue development and pathologies such as cardiovascular disease and cancer …

Hepatocellular carcinoma (HCC), as the fifth most common malignant cancer, develops and
progresses mostly in a cirrhotic liver where stiff nodules are separated by fibrous bands …

The extracellular matrix (ECM) is extensively remodeled in tumor tissues. Overproduction of
collagens, pathological collagen crosslinking and alignment of fibers are major processes …

The tumor micro-environment (TME) of hepatocellular carcinoma (HCC) consists out of
cirrhotic liver tissue and is characterized by an extensive deposition of extracellular matrix …

Cancer progression is regulated by multiple factors of extracellular matrix (ECM).
Understanding how cancer cells integrate multiple signaling pathways to achieve specific …

Intratumoral heterogeneity is a negative prognostic factor for cancer and commonly
attributed to microenvironment-driven genetic mutations and/or the emergence of cancer …