Female mice deficient in steroid 5α-reductase type 1 have a decreased litter size. The
average litter in homozygous deficient females is 2.7 pups vs. 8.0 pups in wild type controls …

Successful delivery of the fetus (parturition) depends on coordinate interactions between the
uterus and cervix. A majority (70%) of mice deficient in the type 1 isozyme of steroid 5α …

Mice lacking steroid 5α-reductase 1 and 2 were produced by gene targeting and breeding.
Male mice without 5α-reductase 2 or without both enzymes had fully formed internal and …

Two steroid 5 alpha-reductase isozymes designated type 1 and 2 synthesize 5 alpha-
reduced androgens and other 5 alpha-reduced steroid hormones. Naturally occurring …

There are two steroid 5α-reductase isoenzymes, designated type 1 and type 2, in mammals
and recent experiments show that each plays a unique physiological role. In this article, the …

The enzyme 5α-reductase plays a key role on several brain functions controlling the
formation of anxiolytic/anesthetic steroids derived from progesterone and …

Testosterone is required for normal development of the male reproductive tract. Synthesis of
testosterone occurs in the Leydig cells and is dependent upon the expression of several …

5α-Androstane-3α, 17β-diol (androstanediol) is the predominant androgen in immature
mouse testes, and studies were designed to investigate its pathway of synthesis, the steroid …

ABSTRACT The enzyme 5α‐reductase (5α‐R) is present in many mammalian tissues,
including the brain. The physiological importance of 5α‐R in the brain derives from its …

Psychological, physical and/or immune stressors during pregnancy are associated with
negative birth outcomes, such as preterm birth and developmental abnormalities. In rodents …