In this study, we evaluated the cytotoxic activity and antiproliferative potency of novel
octahydropyrazin [2, 1-a: 5, 4-a′] diisoquinoline derivatives (1–7) in MCF-7 and MDA-MB …

Abstract Evaluation of the cytotoxicity of novel octahydropyrazin [2, 1-a: 5, 4-a′]
diisoquinoline derivatives (1a–2c) employing a 3-(4, 5-dimethylthiazol-2-yl)-2, 5 …

Objective The aim of the current study was to examine the anticancer activity and the
detailed mechanism of novel diisoquinoline derivatives in human gastric cancer cells (AGS) …

Different quinazoline derivatives have showed wide spectrum of pharmacological activities.
Some 3-(arylideneamino)-phenylquinazoline-4 (3H)-ones have been reported to possess …

Background: The putative pharmacophore of a naturally cytotoxic limonoid haperforin B1, E-
5-iodomethylene-6, 6-dimethyl-5, 6-dihydropyran-2-one (IDDP) was synthesized and its …

Background A and B rings of the steroidal microtubule disruptor, 2-methoxyestradiol, and its
analogs can be mimicked with a tetrahydroisoquinoline (THIQ) core. THIQs are cytotoxic …

Previous studies have suggested that quinazolinone derivatives are potent apoptosis-
inducing agents in various cancer cell lines. In the present study, we have investigated …

As our continuing research, a series of 2-aryl-8-OR-3, 4-dihydroisoquinolin-2-ium bromides
were evaluated for cytotoxic activity on cancer cells and apoptosis induction in the present …

Malignant neoplasms are one of the leading causes of death worldwide and hematologic
malignancies, including acute leukemia (AL) is one of the most relevant cancer types …

Abstract A series of 4-(4-substituted piperazin)-5, 6, 7-trialkoxy quinazoline was prepared by
conventional heating methods. Among these compounds, the crystal structure of compound …