Preparation and in vitro/in vivo evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles

L Zhen, Q Wei, Q Wang, H Zhang… - Pharmaceutical …, 2020 - Taylor & Francis
Gingerol, an active herbal ingredient of ginger has various bioactivities such as anti-
neurodegenerative disease, anti-inflammatory and so on. The aim of the present study was …

Ischemic brain treated with 6-gingerol loaded mucoadhesive nanoemulsion via intranasal delivery and their comparative pharmacokinetic effect in brain

N Ahmad, R Ahmad, M Amir, MA Alam… - Journal of Drug Delivery …, 2021 - Elsevier
Abstract Background 6-Gingerol (GRL), as an antioxidant nonvolatile, phenolic component
of ginger showed a capable function in the treatment of cerebral ischemia but their poor …

Formulation, characterization, and pharmacokinetic studies of 6-gingerol-loaded nanostructured lipid carriers

Q Wei, Q Yang, Q Wang, C Sun, Y Zhu, Y Niu, J Yu… - AAPS …, 2018 - Springer
In this study, an optimized nanostructured lipid carriers (NLCs) were developed and
investigated for improving the solubility and oral availability of 6-Gingerol (6G), an active and …

Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo

Z Song, R Feng, M Sun, C Guo, Y Gao, L Li… - Journal of colloid and …, 2011 - Elsevier
The aim of this study was to assess the potential of new copolymeric micelles to modify the
pharmacokenetics and tissue distribution of Curcumin (CUR), a hydrophobic drug. In the …

Formulation and in vitro evaluation of quercetin loaded polymeric micelles composed of pluronic P123 and Da-tocopheryl polyethylene glycol succinate

L Zhao, Y Shi, S Zou, M Sun, L Li… - Journal of biomedical …, 2011 - ingentaconnect.com
The objective of this study was to develop a polymeric delivery system to improve the
solubility and biological activity of Quercetin (QT). QT loaded mixed micelles, composed of …

Novel anionic polymer as a carrier for CNS delivery of anti-Alzheimer drug

SL Jakki, YV Ramesh, K Gowthamarajan, V Senthil… - Drug Delivery, 2016 - Taylor & Francis
Natural and plant-based polymers could be used for control release of drugs and also helps
in targeting drug to the site of action. The main objective of present work was to check the …

Anti-proliferative potential of quercetin loaded polymeric mixed micelles on rat C6 and human U87MG glioma cells

S Paranthaman, CA Uthaiah, RAM Osmani, U Hani… - Pharmaceutics, 2022 - mdpi.com
Quercetin (Qu) is a natural flavonoid present in many commonly consumed food items and is
also identified as a potential anticancer agent. The present study evaluates the Qu-loaded …

PLGA-PEG-PLGA triblock copolymeric micelles as oral drug delivery system: In vitro drug release and in vivo pharmacokinetics assessment

X Chen, J Chen, B Li, X Yang, R Zeng, Y Liu… - Journal of colloid and …, 2017 - Elsevier
Abstract Poly (d, l-lactide-co-glycolide)-poly (ethylene glycol)-poly (d, l-lactide-co-glycolide)
triblock copolymers (PLGA-PEG-PLGA) has been proven to be desirable for anti-cancer …

Improved oral bioavailability, cellular uptake, and cytotoxic activity of zingerone via nano-micelles drug delivery system

Z Ge, Q Wang, Q Zhu, M Yusif, J Yu… - Journal of …, 2021 - Taylor & Francis
Herein, a nano-micelle drug delivery system was developed to orally improved zingerone's
bioavailability and its antitumor effect. Indeed, zingerone-loaded d-α-tocopheryl …

Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation

Y Xu, Q Wang, Y Feng, CK Firempong, Y Zhu… - Journal of functional …, 2016 - Elsevier
The purpose of this study was to develop a [6]-Gingerol-loaded self-microemulsifying drug
delivery system ([6]-Gingerol-SMEDDS) for oral administration and enhanced bioavailability …