ABSTRACT Stromelysins (namely MMP-3, MMP-10, and MMP-11) are zinc-dependent
endopeptidases that are a subclass of MMPs that help with tissue remodeling and …

Stromelysins (namely MMP-3, MMP-10, and MMP-11) are zinc-dependent endopeptidases
that are a subclass of MMPs that help with tissue remodeling and extracellular matrix (ECM) …

Stromelysins are a matrix metalloproteinase (MMP) family member—a zinc-dependent
endopeptidase responsible for the breakdown of the extracellular matrix (ECM). However …

Effective inhibitors of matrix metalloproteinases (MMPs), a family of connective tissue-
degrading enzymes, could be useful for the treatment of diseases such as cancer, multiple …

Matrix metalloproteinases (MMPs) is an important new class of therapeutic targets for the
treatment of diseases characterized by excessive extracellular matrix degradation and/or …

In an effort to develop alternatives to hydroxamate-based matrix metalloproteinase inhibitors
(MPIs), we have utilized the drug discovery program LUDI enhanced with the structural …

Three-dimensional quantitative structure− activity relationship (3D-QSAR) models have
been obtained using comparative molecular field analysis (CoMFA) for a novel series of …

The binding of two 5‐substituted‐l, 3, 4‐thiadiazole‐2‐thione inhibitors to the matrix
metalloproteinase stromelysin (MMP‐3) have been characterized by protein crystallography …

Background: Stromelysin belongs to a family of zinc-dependent endopeptidases referred to
as matrix metalloproteinases (MMPs, matrixins) because of their capacity for selective …

A novel class of nonpeptide inhibitors of stromelysin (MMP-3) has been discovered with the
use of mass spectrometry. The method relies on the development of structure–activity …