A transmembrane extracellular matrix receptor of the integrin family, alpha 6 beta 4, is a
component of the hemidesmosome, an adhesion complex of importance in epithelial cell …

Many epithelial cells appear to use cell-substratum adhesion complexes known as
hemidesmosomes as the main means of anchorage to the connective tissue. Initially …

As basal cells of stratified squamous epithelia become migratory in response to wounding,
they lose their cell-substrate adhesion junctions, the hemidesmosomes. We report here …

The alpha 6 beta 4 integrin is structurally distinct from all the other known integrins because
the cytoplasmic domain of beta 4 is unusually large and contains four type III fibronectin-like …

Hemidesmosomes are adhesion structures that mediate anchorage of epithelial cells to the
underlying basement membrane. We have previously shown that the α6β4 integrin can …

To examine the function of the alpha 6 beta 4 integrin we have determined its ligand-binding
ability and overexpressed two potentially dominant negative mutant beta 4 subunits, lacking …

Basal cells of stratified epidermis are anchored to the basement membrane zone (BMZ) of
skin via hemidesmosomes. We previously identified integrin alpha 3 beta 1, in focal …

The alpha 6/beta 4 complex is a member of the integrin family of adhesion receptors. It is
found on a variety of epithelial cell types, but is most strongly expressed on stratified …

The integrin heterodimer alpha 6 beta 4 is expressed in many epithelia and in Schwann
cells. In stratified epithelia, alpha 6 beta 4 couple with BPAG1-e and BPAG2 to form …

Antisera that recognize the alpha 6 and beta 4 subunits of integrins were found by
immunoelectron microscopy to localize to hemidesmosomes in the basal cells of mouse …