DNA methylation might have a significant role in preventing normal differentiation in
pediatric cancers. We used a genomewide method for detecting regions of CpG methylation …

The Sonic hedgehog (Shh) pathway is aberrantly activated in a subset of the most common
malignant pediatric brain tumor, medulloblastoma (MB). Shh pathway activity is measured …

Medulloblastomas exhibit an array of diverse cytogenetic abnormalities. To evaluate the
significance of epigenetic rather than genetic lesions in medulloblastomas and other …

Genetic and epigenetic alterations are essential for the initiation and progression of human
cancer. We previously reported that primary human medulloblastomas showed extensive …

Existing microarray-based approaches for screening of DNA methylation are hampered by a
number of shortcomings, such as the introduction of bias by DNA copy-number imbalances …

Neuroblastoma is a very heterogeneous tumor of childhood. The clinical spectra range from
very aggressive metastatic disease to spontaneous regression, even without therapy …

Epigenetic alterations, that is, disruption of DNA methylation and chromatin architecture, are
now acknowledged as a universal feature of tumorigenesis. Medulloblastoma, a clinically …

Lymphoblastoid cell line (LCL) is a common tool to study genetic disorders. However, it has
not been fully characterized to what degree LCLs preserve the in vivo status of non-genetic …

DNA methylation of cytosines in CpG sites throughout the genome is an epigenetic mark
contributing to gene expression regulation. DNA methylation patterns are specific to tissue …

Epigenetic regulation including DNA methylation plays an important role in several
differentiation processes. We profiled global DNA methylation in the neural differentiation of …