Spheroids are three-dimensional cell aggregates expressing histotypic organisation in vitro
comparable to tissue continuity in vivo. They can be prepared from normal tissue and from …

An in vitro model is presented to test the invasiveness of human brain tumour derived cells.
Spheroids of brain tumours are confronted with autologous spheroids of human dermal …

Background: The use of three-dimensional in vitro models of brain tumor invasion has
provided a system for reconstructing some of the cellular microenvironments present in the …

In the past, in vitro studies of invasion and tumor progression were performed primarily using
cancer cells cultured on a flat, two‐dimensional (2D) surface in a monolayer. In recent years …

Object. The aim of this study was to develop an improved animal model for brain tumor
study. The need for better and more relevant brain tumor models is generally acknowledged …

During the last three decades multicellular spheroids of both normal and malignant cells
have been used as model systems for studying three-dimen sional growth and differentiation …

✓ Tumor tissue from seven human gliomas was maintained in long-term agar overlay culture
as multicellular organotypic spheroids. Light microscopic and ultrastructural observation of …

The growth of tumour cells as three‐dimensional multicellular spheroids in vitro has led to
important insights in tumour biology, since properties of the in vivo‐tumour such as …

Object. The goal of this study was to evaluate whether there is any relationship between
survival of patients with brain tumor and tumor proliferation or tumor invasion in vitro …

The invasiveness of human intracranial tumours was studied in an organ culture system.
Biopsies from six glioblastomas, four astrocytomas, two mixed gliomas, one ependymoma …