Zinc finger proteins are abundant in the human proteome and are responsible for a variety of
functions. The domains that constitute zinc finger proteins are compact spherical structures …

The design of DNA‐binding proteins for the specific control of the gene expression is one of
the big challenges for several research laboratories in the post‐genomic era. An artificial …

Within the last 20 years, the understanding of the biology of the 'classical'or Cys2His2 zinc
finger domain has progressed rapidly from the initial identification of the zinc finger as a …

Background Information on the occurrence of zinc finger protein motifs in genomes is crucial
to the developing field of molecular genome engineering. The knowledge of their target DNA …

Conspectus The understanding of gene regulation and the structure and function of the
human genome increased dramatically at the end of the 20th century. Yet the technologies …

The modular assembly (MA) method of generating engineered zinc finger proteins (ZFPs)
was the first practical method for creating custom DNA-binding proteins. As such, MA has …

Zinc finger proteins are among the most extensively applied metalloproteins in the field of
biotechnology owing to their unique structural and functional aspects as transcriptional and …

Recent studies provide a glimpse of future potential therapeutic applications of custom-
designed zinc finger proteins in achieving highly specific genomic manipulation. Custom …

In this review, we summarize design strategies for generating proteins with desired
sequences such as long contiguous base pairs and diverse sequence specificities based on …

Proteins control most biological reactions and the disorder of their expression level causes
many diseases. The advent of genomic sequencing and the availability of the complete …