Protection against intracellular pathogens or tumor antigens requires T-cell mediated
responses. Recently, it has become apparent that protection against disease correlates with …

M emory T-cell responses are of vital importance in understanding the host's immune
response against pathogens and cancer cells and to begin establishing the correlation of …

Pre-existing T cell memory provides substantial protection against viral, bacterial, and
parasitic infections. The generation of protective T cell memory constitutes a primary goal for …

T lymphocytes play a central role in the generation of a protective immune response in many
microbial infections. After immunization, dendritic cells take up microbial antigens and traffic …

T Memory Cells: Quality not Quantity Dispatch Page 1 T Memory Cells: Quality not Quantity
Dispatch Jonathan Sprent Immunological memory to pathogens is associated with clonal …

Effective immunization induces the development of populations of robust effector
lymphocytes specific for the immunizing antigens. Amongst them are cytotoxic/CD8+ T …

Immunity towards intracellular pathogens is often dependent upon the generation of CD8+
memory T cells, which provide long-lasting and effective protection. Over the past few years …

Adaptive immunity is characterized by the ability to form long-lived immunological memory.
Upon re-exposure to antigen, memory T cells respond more rapidly and robustly than naïve …

Vaccines, arguably the single most important intervention in improving human health, have
exploited the phenomenon of immunological memory. The elicitation of memory T cells is …

A hallmark of the antigen‐specific B and T lymphocytes of the adaptive immune system is
their capacity to “remember” pathogens long after they are first encountered, a property that …