Multi-drug resistance (MDR) to anticancer drugs is the primary impediment to successful
treatment of cancer. Hunting for new compounds with potent anti-MDR activity is an effectual …

Abstract A series of 6-substituted 1, 4-naphthoquinone oxime derivatives were synthesized
and evaluated for their in vitro cytotoxicity against four cancer cell lines and one normal cell …

Cancer is a leading cause of death worldwide. Multidrug resistance (MDR) is a main reason
of chemotherapy failure in many patients and is often related to overexpression of ATP …

Multidrug resistance in tumor cells poses a major obstacle to efficient chemotherapy.
Several types of agents have been recognized as multidrug resistance inhibitors, among …

The quinoxaline core is a promising scaffold in medicinal chemistry. Multiple quinoxaline
derivatives, such as the topoisomerase IIβ inhibitor XK-469 and the tissue transglutaminase …

To examine the effect of hydrophobicity on the anticancer activity of 1, 4-naphthoquinone
derivatives, a series of compounds bearing a 2-O-alkyl-, 3-C-alkyl-or 2/3-N-morpholinoalkyl …

Employing a rational design of thioaryl naphthylmethanone oxime ether analogs containing
functional properties of various anticancer drugs, a series of compounds were identified that …

Multidrug resistance mediated by P-glycoprotein in cancer cells has been a major issue that
cripples the efficacy of chemotherapy agents. Aimed for improved efficacy against resistant …

Drug resistance is the major cause of the failure of cancer chemotherapy, so one of the most
important features in developing effective cancer therapeutic strategies is to overcome drug …

In the current study, a series of novel quinolinedione-linked sulfonylpiperazine derivatives
have been reported as NQO1-directed antitumor agents. A majority of compounds in this …