Bacterial sepsis is a serious life-threatening condition caused by an excessive immune
response to infection. B-1 cells differ from conventional B-2 cells by their distinct phenotype …

Background Sepsis morbidity and mortality are aggravated by acute lung injury (ALI) or
acute respiratory distress syndrome (ARDS). Mouse B-1a cells are a phenotypically and …

Sepsis is a life-threatening syndrome caused by anomalous host response to infection. The
pathogenesis of sepsis is complex, and immune dysfunction is the central link in its …

Sepsis is a life-threatening yet common disease, still posing high mortality worldwide.
Sepsis-related deaths primarily occur during immunosuppression; the disease can hamper …

Dysregulated host immune homeostasis in sepsis is life-threatening even after a
successfully treated bacterial infection. Lipopolysaccharide (LPS) is an endotoxin that is a …

Microbes activate pattern recognition receptors to initiate adaptive immunity. T cells affect
early innate inflammatory responses to viral infection, but both activation and suppression …

Sepsis syndrome is caused by inappropriate immune activation due to bacteria and
bacterial components released during infection. This syndrome is the leading cause of death …

The inflammatory response involving interleukin-1β (IL-1β) has been thought to play an
important role in the development of late-phase sepsis. However, in this study, we wanted to …

B 1 cells are evolutionarily conserved innate‐like cells that share many features with
macrophages. It has also been established that B 1 cells have a close developmental …

B-1 cells are a peculiar subpopulation of B cells found in the peritoneal and pleural cavities
in mice. These cells are typically IgM+ and CD11b+. B-1 cells are able to migrate from the …