Human coronary artery endothelial cells (HCAECs) have the potential to undergo fibrogenic
endothelial–mesenchymal transition (EndMT), which results in matrix-producing fibroblasts …

Cardiac fibrosis is characterized by over‐deposition of extracellular matrix (ECM) proteins
and over‐proliferation of cardiac fibroblast, and contributes to both systolic and diastolic …

Cardiac fibrosis is associated with diverse heart diseases. In response to different
pathological irritants, cardiac fibroblasts may be induced to proliferate and differentiate into …

The modulation of vascular smooth muscle cell (VSMC) phenotype during cellular
proliferation and migration may represent a potential therapeutic approach for vascular …

Rationale: The miR-143/145 cluster is highly expressed in smooth muscle cells (SMCs),
where it regulates phenotypic switch and vascular homeostasis. Whether it plays a role in …

Endothelial-mesenchymal transition (EndMT) is closely associated with embryogenesis,
injury restitution, tissue neogenesis, tumor progressions and viscera fibrosis. EndMT may …

Aims Endothelial-to-mesenchymal transition (EndMT) contribute to diabetic cardiac fibrosis,
the underlying mechanisms are poorly understood. In the study, we aimed to investigate the …

Excessive proliferation of cardiac fibroblasts (CFs) and their transdifferentiation into
myofibroblasts leads to expression of α‐smooth muscle actin (α‐SMA), as well as excessive …

Background/Aims: In our previous study, we demonstrated that elevated expression of miR-
328 is a potent determinant of cardiac fibrosis during myocardial infarction (MI). In the …

OBJECTIVE: To discover the mechanisms of miR-154 affecting myocardial fibrosis.
PATIENTS AND METHODS: Human cardiac fibroblasts (CFs) were cultured in medium …