OCT4 is a transcription factor critical for the pluripotency of human embryonal stem (ES) and
induced pluipotency stem (IPS) cells. OCT4 is commonly expressed in germ-cell tumors as …

Octamer-binding transcription factor 4 (Oct4), a homeodomain transcription factor, is well
established as a master factor controlling the self-renewal and pluripotency of pluripotent …

ABSTRACT The transcription factor OCT3/4 (also known as POU5F1 and Oct4) is regarded
as one of the key regulators of pluripotency. Expression in nonmalignant cells is restricted to …

Naive and primed pluripotent stem cells (PSCs) and germ cells express the Oct4 gene. The
Oct4 gene contains two cis-regulatory elements, the distal enhancer (DE) and proximal …

Abstract The Oct-3/4 transcription factor sustains embryonic stem (ES) cell self-renewal and
is a dose-dependent cell fate determinant. In the adult male, its expression is restricted to …

Germ cell tumours (GCTs) are one of the most threatening malignancies in young men and
women. Although several reports have suggested the importance of OCT4 in human GCTs …

Epithelial ovarian cancer (EOC) remains the most lethal of all the gynaecological
malignancies with drug resistance and recurrence remaining the major therapeutic barrier in …

OCT4 is considered a main regulator of embryonic stem cell pluripotency and self renewal
capacity. It was shown that relevant OCT4 expression only occurs in cells of embryonic …

Abstract Octamer-binding protein 4 (OCT4) is a key player in pluripotent embryonic stem
(ES) cells and is essential for the generation of induced pluripotent stem cells. Recently …

The Oct‐4 transcription factor, a member of the POU family that is also known as Oct‐3 and
Oct3/4, is expressed in totipotent embryonic stem cells (ES) and germ cells, and it has a …