Transgenic mice expressing high levels of the BclxL or Bcl2 proteins in the male germinal
cells show a highly abnormal adult spermatogenesis accompanied by sterility. This appears …

Bclw is a death-protecting member of the Bcl2 family of apoptosis-regulating proteins. Mice
that are mutant for Bclw display progressive and nearly complete testicular degeneration …

Bax is a multidomain, proapoptotic member of the Bcl-2 family that is required for normal
spermatogenesis in mice. Despite its proapoptotic function, previous results found that Bax …

Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the
embryo and adult. The recently isolated bcl-w gene encodes a pro-survival member of the …

During normal spermatogenesis, more than half of the germ cells undergo apoptosis, but the
physiological significance and molecular mechanisms of this programmed cell death are …

Mature sperm are the product of a precisely regulated developmental sequence in which
germ cell proliferation, differentiation, self‐renewal and apoptosis are carefully controlled …

The significance of cell death occurring during spermatogenesis is a subject of interest
because of its potential medical importance. Unfortunately, the field has been difficult for …

Using immunohistochemical techniques and Western blot analysis, the possible role of Bcl‐
2 family members Bax, Bcl‐2, Bcl‐xs, and Bcl‐xl in male germ cell density‐related apoptosis …

Apoptosis is a critical process for regulating both the size and the quality of the male and
female germ lines. In this review, we examine the importance of this process during …

Restricted germ cell loss through apoptosis is initiated in the fetal gonad around embryonic
day 13.5 (E13. 5) as part of normal germ cell development. The mechanism of this germ cell …