Using agarose gel electrophoresis we confirmed that Ledakrin is capable of incurring
covalent crosslinking in pBR322 plasmid DNA and also in poly (dGdC) in the presence of a …

Adducts generated in vitro by the reaction of 1-nitroacridines with poly (dN) s in the presence
of dithiothreitol were used to identify a kind of nucleic base involved in the formation of …

Abstract Ledakrin [1-nitro-9-(3′-dimethylamino-N-propylamino) acridine], an antitumor drug
of the 1-nitro-9-aminoacridine family, was able to induce DNA-protein crosslinks in intact …

To define a critical lesion in presumable target DNA cause in vivo by the antitumor and
cytotoxic 1-nitroacridines, Ehrlich ascites tumor (Eat) cells implanted into mice, HeLa cells …

A 32 P-post-labeling method has been employed to detect DNA adducts formed by
derivatives of nitro-9-aminoacridine in both cellular and non-cellular systems. The treatment …

To determine whether the toxic effects and changes in many cell functions caused by
antitumor 1-nitroacridines are related to their enzymatically mediated covalent interstrand …

Materials and methods Chemicals. Ledakrin and its analogues were kindly provided by the
late Professor Andrzej Led6chowski from this Department. Hydroxylapatite (Bio-Gel HTP …

Abstract Nitracrine (Ledakrin, 1-nitro-9-(3, 3-N, N-dimethylaminopropylamino)-acridine) is of
interest as a DNA intercalator and alkylator with very high cytotoxic potency, especially …

Ledakrin and seven other antitumor and cytotoxic derivatives of 1-nitro-9-aminoacridine
were shown to induce DNA-single strand breaks in HeLa S3 cells as found by alkaline …

Earlier evidence, in Part I of this paper, has shown that cytotoxic and antitumor 1-
nitroacridines did not primarily exert their potent inhibitory effects on cultured mammalian …