Abstract Overexpression of cyclooxygenase 2 (COX-2) is frequently found in early and
advanced lung cancers. However, the precise regulatory mechanism of COX-2 in lung …

Cleavage and polyadenylation specific factor 4 (CPSF4), a member of CPSF complex, plays
a key role in mRNA polyadenylation and mRNA 3′ ends maturation. However, its possible …

Aberrant expression of COX-2 occurs in many types of malignancies including colon and
lung cancers, and is implicated in development and progression of cancer. The molecular …

CPSF4 was identified as a crucial tumorigenic factor in lung cancer development. However,
its precise function and the underlying molecular mechanisms in colon cancer progression …

Abstract Cyclooxygenase-2 (COX-2) is highly expressed in tumor cells and has been
regarded as a hallmarker for cancers, but the excise regulatory mechanism of COX-2 in …

We have been investigating gene expression profiles in non-small cell lung cancers
(NSCLCs) to identify molecules involved in pulmonary carcinogenesis and select which …

Lung cancer is the leading cause of malignant tumor-related deaths worldwide. The
presence of tumor-initiating cells in lung cancer leads to tumor recurrence, metastasis, and …

Abstract Cyclooxygenase-2 (COX-2) is overexpressed in a variety of human epithelial
cancers, including lung cancer, and is highly associated with a poor prognosis and a low …

The objective of the present study was to investigate whether cyclooxygenase-2 (COX-2) is
associated with malignancy, and to investigate its molecular mechanisms in human lung …

Background Vascular endothelial growth factor (VEGF) expression is up-regulated via a
cyclooxygenase-2 (COX-2)-dependent mechanism in non-small cell lung cancer (NSCLC) …