Cell cycle arrest in response to DNA damage involves protein stabilization and consequent
upregulation of p53, which induces transcription of cyclin-dependent kinase inhibitor p21 …

The inhibitor of cyclin-dependent kinases p21CDKN1A plays a fundamental role in several
pathways involved in the DNA damage response, like checkpoint-mediated cell cycle arrest …

The tumor suppressor p53 regulates transcription positively and negatively, depending on
the target gene. Whereas p53 induces transcription through direct interaction with promoter …

The tumor suppressor p53 is an important cellular protein, which controls cell cycle
progression. Phosphorylation is one of the mechanisms by which p53 is regulated. Here we …

Among cell cycle regulatory proteins that are activated following DNA damage, the cyclin-
dependent kinase inhibitor p21CDKN1A plays essential roles in the DNA damage response …

Background p53 is the most studied tumor suppressor and its overexpression may or may
not cause cell death depending upon the genetic background of the cells. p53 is degraded …

DNA damage increases p53 protein levels and activates transcription of the p21 gene. The
p21 protein binds to and inhibits cdk2 kinase, causing G1 arrest. Here, we have investigated …

p21 is a member of the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors that
includes p21, p27, and p57. Recent studies have suggested that Cdk2 activity may promote …

The p53 transcriptional network orchestrates alternative stress responses such as cell-cycle
arrest and apoptosis. Here we investigate the mechanism of differential expression of p21, a …

p53 is extensively posttranslationally modified in response to various types of cellular stress.
Such modifications have been implicated in the regulation of p53 protein levels as well as its …