An advantage of targeted gene therapy is the potential for effectively delivering anti-vascular
and antitumor therapy directly to the site of the tumor, thus maximizing therapeutic efficacy …

BACKGROUND: Recently, considerable efforts have been directed toward antivascular
therapy as a new modality to treat human cancers. However, targeting a therapeutic gene of …

Adenoviral vectors, which have targeting ligands for tumor cells on the capsid, no natural
tropism, and carry a therapeutic payload should be constructed soon and tested in pre …

Gene therapy and molecular-genetic imaging have faced a major problem: the lack of an
efficient systemic gene delivery vector. Unquestionably, eukaryotic viruses have been the …

A recent target of cancer gene therapy is tumor angiogenesis. An appealing feature of gene
therapy targeting the tumor vasculature is that it is readily accessible, particularly when the …

The application of cancer gene therapy has heretofore been restricted to local, or
locoregional, neoplastic disease contexts. This is owing to the lack of gene transfer vectors …

Gene therapy strategies in cancer have remained an active area of preclinical and clinical
research. One of the current limitations to successful trials is the relative transduction …

The adaptation of gene therapy strategies to treat tumors has broadened the potential
armamentarium of anticancer strategies to include approaches for local control of tumor …

Tumor-associated vasculature is a relatively accessible component of solid cancers that is
essential for tumor survival and growth, providing a vulnerable target for cancer gene …

Based on the observation that the growth of solid tumors is dependent on the formation of
new blood vessels, therapeutic strategies aimed at inhibiting angiogenesis have been …