Among the first cells to invade a site of infection, polymorphonuclear neutrophils (PMN) play
an important role in the control of numerous infections. While PMN are considered critical for …

Successful host defense against numerous pulmonary infections depends on bacterial
clearance by polymorphonuclear leukocytes (PMNs); however, excessive PMN …

Tuberculosis (TB) is caused by the intracellular bacteria Mycobacterium tuberculosis, and
kills more than 1.5 million people every year worldwide. Immunity to TB is associated with …

The hallmark of pulmonary tuberculosis is the granuloma, which consists predominantly of
lymphocytes and macrophages and promotes immune-cell interaction with the causative …

During chronic infection with Mycobacterium tuberculosis (Mtb), bacilli multiplication is
constrained within lung granulomas until excessive inflammation destroys the lung …

Mycobacterium tuberculosis (Mtb) is the intracellular pathogen that causes the disease,
tuberculosis. Chemokines and chemokine receptors are key regulators in immune cell …

CD8 T cell immune responses are known not to be essential during the initial stages of
infection with Mycobacterium tuberculosis (Mtb), but their presence becomes important as …

Mycobacterium tuberculosis infection (Mtb) results in the generation of protective cellular
immunity and formation of granulomatous structures in the lung. CXCL13, CCL21, and …

Necrotizing granulomas, exacerbating pathogenesis and neutrophil influx at the site of
infection are hallmarks of active pulmonary tuberculosis (TB) in humans. The role of …

Neutrophil infiltration into tuberculous granulomas is often associated with higher bacteria
loads and severe disease but the basis for this relationship is not well understood. To better …