Adenovirus infection results in the suppression of cellular protein synthesis, but the
mechanism has not been established. In this report we demonstrate that the shut-off of …

The mechanisms controlling early adenovirus gene expression in vivo have been studied
using inhibitors of protein synthesis. When inhibitors were added shortly before or at the …

The dl331 mutant of adenovirus serotype 5 fails to produce virus-associated (VA) RNAI, and
cells infected with this mutant do not synthesize proteins efficiently at late times in infection …

The late phase of adenovirus (Ad) infection is marked by the inhibition of cellular protein
synthesis, the preferential translation of late viral mRNAs and resistance to the translation …

Viral mRNA species synthesized early in adenovirus type 2 infection in the presence of
cycloheximide were compared with those synthesized in the absence of drug or in the …

In the absence of VA RNA,, protein synthesis in adenovirus-infected HeLa cells fails at late
times of infection because of defective initiation. The defect is due to the activation of a …

The translational efficiency of mRNA molecules transcribed from plasmid DNA transfected
into COS-1 monkey cells can be increased 10-to 20-fold by the coexpression of the …

Eight structural polypeptides of adenovirus type 2 can be identified in the infected HeLa cell.
All are stable; none is a precursor of another. The various polypeptides are synthesized at …

A substantial body of data, largely derived from study of cell extracts, indicates that protein
synthesis in adenovirus-infected cells requires VA RNA 1 at late times of infection to prevent …

The virus-associated VAI RNA of adenovirus is a small, RNA polymerase III-transcribed
species required for efficient translation of mRNAs late after infection. Deletion mutant dl331 …