Previous work by our group showed that aged C57BL/6 mice develop an altered innate and
adaptive immune response to Candida albicans and are more susceptible to systemic …

The prevalence of opportunistic fungal infections has increased dramatically among the
aged population in recent years. This work investigated the effect of ageing on murine …

To improve our understanding of the role natural-immunity cells play in regulating the
immune response to Candida albicans (CA) we compared local versus systemic effects of …

Oropharyngeal candidiasis is associated with defects in cell‐mediated immunity, and is
commonly seen in immunocompromised patients. We have previously shown that T‐cell …

Patients with chronic mucocutaneous candidiasis (CMC) are selectively unable to clear the
yeast Candida, which results in persistent debilitating infections affecting the skin, nails, and …

Macrophages co-incubated with Candida albicans strain CR1 in vitro showed early signs of
apoptosis, but evolved to necrosis after 2 h. In this study, we investigated whether strain CR1 …

Host resistance against infections caused by the yeast Candida albicans is mediated
predominantly by polymorphonuclear leukocytes and macrophages. Antigens of Candida …

We administered a neutralizing monoclonal antibody to tumor necrosis factor (TNF) during
infection with Candida albicans in normal and granulocytopenic mice. Mice were rendered …

The in vitro production of TNF-α and IFN-γ in response to Candida albicans was investigated
in wild-type, TLR2-/-and TLR4-/-murine cells. TLR2-/-resident peritoneal macrophages …

Phagocytic cells such as neutrophils and macrophages are potential components of the
immune defense that protects mammals against Candida albicans infection. We have tested …