Susceptibility to mycobacterial infection has long been associated with defects in T cell
immunity, such as those conferred by HIV infection or iatrogenic immune suppression …

Mendelian defects in interferon-γ (IFN-γ) signaling most commonly lead to infection with
nontuberculous mycobacteria. Mutations have been identified in the genes encoding IFN-γ …

Selective susceptibility to poorly pathogenic mycobacteria, such as bacille Calmette—
Guérin vaccine and environmental non-tuberculous mycobacteria, has long been suspected …

Primary immunodeficiency diseases (PIDs) represent a large and heterogeneous group of
more than 120 different entities, most of which have now been genetically characterized …

Individuals with inherited disorders of interferon-γ (IFN-& gamma)-mediated immunity
appear to be specifically vulnerable to mycobacterial infections. The severity of clinical …

Understanding molecular immunity against mycobacterial infection is critical for the
development of effective strategies to control tuberculosis (TB), which is a major health issue …

Clinical disease caused by the agent of tuberculosis, Mycobacterium tuberculosis, and by
less virulent mycobacteria, such as bacillus Calmette-Guérin (BCG) vaccines and …

Abstract Purpose of Review Many genetic conditions predispose affected individuals to
opportunistic infections. A number of immunodeficiency diseases, including genetic defects …

The integrity of the interferon (IFN)-γ circuit is necessary to mount an effective immune
response to intra-macrophagic pathogens, especially Mycobacteria. Inherited monogenic …

Severe disseminated infections with weakly virulent mycobacteria, Salmonella and/or
Mycobacterium tuberculosis, in otherwise healthy individuals, characterise a recently …