Background An effective malaria transmission-blocking vaccine (TBV) would be a major
advance in the current efforts to eliminate and, ultimately, eradicate malaria. Antibodies …

An ideal malaria vaccine platform should potently induce protective immune responses and
block parasite transmission from mosquito to human, and it should maintain these effects for …

Abstract Background Transmission-blocking vaccines (TBVs) have become a focus of
strategies to control and eventually eliminate malaria as they target the entry of sexual stage …

Background Models of immunity to malaria indicate the importance of CD8+ T cell
responses for targeting intrahepatic stages and antibodies for targeting sporozoite and …

The ookinete surface protein Pfs25 is a macrogamete-to-ookinete/ookinete stage antigen of
Plasmodium falciparum, capable of exerting high-level anti-malarial transmission-blocking …

Background A protective malaria vaccine will likely need to elicit both cell-mediated and
antibody responses. As adenovirus vaccine vectors induce both these responses in …

Transmission-blocking vaccines (TBVs), pioneered by Richard Carter and others, aim to
prevent parasite development in the mosquito vector and are a promising new tool for …

An effective vaccine to reduce malaria transmission is central to control and ultimately
achieve disease eradication. Recently, we demonstrated that antibodies targeting the …

An effective malaria vaccine remains a global health priority. Recombinant adenoviruses are
a promising vaccine platform, and Plasmodium falciparum apical membrane antigen 1 …

We previously demonstrated that boosting with adeno-associated virus (AAV) type 1 (AAV1)
can induce highly effective and long-lasting protective immune responses against malaria …