Background:: Polymorphisms in the interleukin 1β gene (IL-1B-31T/C and IL-1B-511C/T
single nucleotide changes) and in the interleukin 1 receptor anatagonist gene (IL-1RN2 …

OBJECTIVES Host genetic factors, including the IL1 gene cluster, play a key role in
determining the long-term outcome of Helicobacter pylori infection. The aim of the study was …

Abstract Background and Aim: Helicobacter pylori is a major cause of chronic gastritis and
peptic ulcer disease and a definite carcinogen for gastric adenocarcinoma. However, the …

Background: The host genetic factors that determine the clinical outcomes of Helicobacter
pylori‐infected individuals remain unclear. Aim: To elucidate the risks of host interleukin‐1 …

OBJECTIVES The association between interleukin-1 polymorphisms, H. pylori and
increased gastric cancer risk remains controversial. AIMS To compare the prevalence of …

Abstract The interleukin (IL)-1β-511 C/T polymorphism has been shown to be functional and
to contribute to the risk of gastric cancer. However, the relationship between the IL-1β-511 …

Abstract Interleukin (IL)-1 gene polymorphisms are associated with development of gastric
atrophy and with increased risk of gastric carcinoma. A-31C to T base transition in the …

Background Gastric cancer is one of the most common malignancies afflicting the Chinese
population. Polymorphisms in interleukin-1B (IL-1B) and interleukin-1 receptor antagonist (IL …

Abstract Interleukin 2 (IL-2) is a pro-inflammatory cytokine that is mainly synthesized by
immunoregulatory T helper cells and which plays an important role in antitumor immunity …

Studies suggest that IL-1β (encoded by IL-1B gene) is a pro-inflammatory cytokine and
potent inhibitor of gastric acid secretion, which is proposed as a key determinant in gastric …