Using in vivo microdialysis techniques, the effects of RTI‐55 and/or cocaine on extracellular
dopamine (DA) concentrations were measured in the nucleus accumbens (NACC) of freely …

There is a large unmet medical need for cocaine addiction treatments. Studies have
indicated that the dopamine transporter (DAT) is the primary biological target of cocaine, and …

Extensive evidence suggests that the reinforcing effects of cocaine involve inhibition of
dopamine transporters (DAT) and subsequent increases in dopamine (DA) levels in the …

Cocaine is a powerful reinforcing drug that has a variety of pharmacological effects on the
central nervous system. While several binding sites for 3H-cocaine have been identified in …

Cocaine analogs such as 3β‐(4‐iodophenyl) tropane‐2β‐carboxylic acid methyl ester (RTI‐
55 or βCIT) with a higher affinity for the dopamine transporter (DAT) may be potentially …

Cocaine binds and inhibits dopamine transporter (DAT), norepinephrine transporter (NET)
and serotonin transporter. The residues forming cocaine binding sites are unknown. RTI …

Cocaine abuse is a serious health problem in many areas of the world, yet there are no
proven effective medications for the treatment of cocaine dependence. Preclinical studies …

There have been many studies aimed at understanding the role that the dopamine
transporter plays in cocaine abuse. Most studies suggest that inhibition of dopamine uptake …

Drugs that block dopamine uptake often function as positive reinforcers but can differ along
the dimension of strength or effectiveness as a positive reinforcer. The present study was …

Cocaine mediates its powerful reinforcement by binding to recognition sites on the
dopamine(DA) transporter. The phar-macological identity of cocaine recognition sites and …