Few details are known about how the human immunodeficiency virus type 1 (HIV‐1)
genomic RNA is trafficked in the cytoplasm. Part of this process is controlled by the activity of …

Human immunodeficiency virus type 1 (HIV-1) co-opts host proteins and cellular
machineries to its advantage at every step of the replication cycle. Here we show that HIV-1 …

Two cis-acting RNA trafficking sequences (heterogenous ribonucleoprotein A2 (hnRNP A2)-
response elements 1 and 2 or A2RE-1 and A2RE-2) have been identified in HIV-1 vpr and …

hnRNP A2 is a cellular protein that is important for nucleocytoplasmic and cytosolic
trafficking of the HIV-1 genomic RNA. Both hnRNP A2's interaction with HIV-1 RNA and its …

All retroviruses package cellular RNAs into virions. Studies of murine leukemia virus (MLV)
revealed that the major host cell RNAs encapsidated by this simple retrovirus were LTR …

Full-length unspliced human immunodeficiency virus type 1 (HIV-1) RNAs serve dual roles
in the cytoplasm as mRNAs encoding the Gag and Gag-Pol capsid proteins as well as …

Intracellular trafficking of retroviral RNAs is a potential mechanism to target viral gene
expression to specific regions of infected cells. Here we show that the human …

As a member of the retrovirus family, HIV-1 packages its RNA genome into particles and
replicates through a DNA intermediate that integrates into the host cellular genome. The …

HIV-1 Gag can assemble and generate virions at the plasma membrane, but it is also
present in endosomes where its role remains incompletely characterized. Here, we show …

Once transcribed, the nascent full-length RNA of HIV-1 must travel to the appropriate host
cell sites to be translated or to find a partner RNA for copackaging to form newly generated …