Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility

G Esposito, AM Vitale, FPJ Leijten, AM Strik… - Molecular and cellular …, 2007 - Elsevier
Peptidylarginine deiminase 6 (PAD6) is an enzyme that is uniquely expressed in male and
female germ cells. To study the function of this enzyme in vivo we generated mice deficient …

Role for peptidylarginine deiminase enzymes in disease and female reproduction

S Horibata, SA Coonrod… - Journal of Reproduction …, 2012 - jstage.jst.go.jp
The peptidylarginine deiminases (PADs) are a family of calcium-dependent enzymes that
post-translationally convert positively charged arginine residues to neutrally charged …

[HTML][HTML] Potential role for peptidylarginine deiminase 2 (PAD2) in citrullination of canine mammary epithelial cell histones

BD Cherrington, E Morency, AM Struble, SA Coonrod… - PloS one, 2010 - journals.plos.org
Peptidylarginine Deiminases (PADs) convert arginine residues on substrate proteins to
citrulline. Previous reports have documented that PAD2 expression and activity varies …

[HTML][HTML] Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development

X Zhang, X Liu, M Zhang, T Li, A Muth, PR Thompson… - Scientific reports, 2016 - nature.com
Peptidylarginine deiminase (PADI) enzymes are increasingly being associated with the
regulation of chromatin structure and gene activity via histone citrullination. As one of the …

[HTML][HTML] ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets

PW Wright, LC Bolling, ME Calvert, OF Sarmento… - Developmental …, 2003 - Elsevier
Selected for its high relative abundance, a protein spot of MW∼ 75 kDa, pI 5.5 was cored
from a Coomassie-stained two-dimensional gel of proteins from 2850 zona-free metaphase …

Peptidylarginine deiminase expression and activity in PAD2 knock-out and PAD4-low mice

JJBC van Beers, AJW Zendman, R Raijmakers… - Biochimie, 2013 - Elsevier
Citrullination, the conversion of peptidylarginine to peptidylcitrulline is catalyzed by
peptidylarginine deiminases (PAD). The expression of PAD isoforms displays great variation …

DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice

LCL Hsu, HY Chen, YW Lin, WC Chu, MJ Lin, YT Yan… - Rna, 2008 - rnajournal.cshlp.org
DAZAP1 (Deleted in Azoospermia Associated Protein 1) is a ubiquitous hnRNP protein that
is expressed most abundantly in the testis. Its ability to shuttle between the nucleus and the …

[HTML][HTML] Expression of peptidylarginine deiminase type 4 in ovarian tumors

L Wang, X Chang, G Yuan, Y Zhao… - International journal of …, 2010 - ncbi.nlm.nih.gov
Abstract Peptidylarginine deiminase type 4 (PADI4) converts arginine residues into citrulline.
The current study focused on the expression of PADI4 in various subtypes of ovary cancers …

Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility

K Tokuhiro, M Ikawa, AM Benham… - Proceedings of the …, 2012 - National Acad Sciences
A disintegrin and metalloproteinase 3 (ADAM3) is a sperm membrane protein critical for both
sperm migration from the uterus into the oviduct and sperm primary binding to the zona …

[HTML][HTML] An essential role for PNLDC1 in piRNA 3′ end trimming and male fertility in mice

Y Zhang, R Guo, Y Cui, Z Zhu, Y Zhang, H Wu, B Zheng… - Cell research, 2017 - nature.com
PIWI-interacting RNAs (piRNAs) are germ cell-specific small non-coding RNAs that are
essential for silencing transposable elements. Substantial efforts in the past decade have …