We previously documented persistent regulation of erythropoietin (Epo) secretion in mice
after a single intramuscular (im) injection of a recombinant adeno-associated virus (rAAV) …

Background Helper‐dependent adenoviral (HD‐Ad) vectors give rise to sustained gene
expression after delivery in a variety of organisms. In particular, we previously documented …

Recombinant adeno-associated viral (rAAV) vectors containing an improved tetracycline
(tet) system of transcriptional regulation are an efficient strategy for the control of long-term …

Anti-transgene immune responses elicited after intramuscular (im) delivery of recombinant
adeno-associated virus (rAAV) have been shown to hamper long-term transgene expression …

Gene therapy is a potential route for the delivery of secreted therapeutic proteins, but
pharmacologic control of expression will generally be required for optimal safety and …

Recombinant adeno-associated virus (rAAV) vector supports long-term transgene
expression from skeletal muscle in most mammals, including human. In some instances, the …

Control of gene expression is important to gene therapy for purposes of both dosing and
safety. In vivo regulation of gene expression was demonstrated following co-injection of two …

Recombinant adeno-associated virus encoding the monkey erythropoietin gene (rAAV-cm-
Epo) was generated and tested for its potential to confer long-term expression of the gene …

Numerous studies have demonstrated the efficacy of the Adeno-Associated Virus (AAV)-
based gene delivery platform in vivo. The control of transgene expression in many protocols …

We reported previously that controlled expression of a foreign gene in response to
tetracycline derivative can be accomplished in mice by the autologous transplantation of …