Maintenance of the lipid composition is important for proper function and homeostasis of the
mitochondrion. In T rypanosoma brucei, the enzymes involved in the biosynthesis of the …

Phosphatidylethanolamine (PE) and phosphatidylserine (PS) are ubiquitously expressed
and metabolically interconnected glycerophospholipids in eukaryotes and prokaryotes. In …

Although the protozoan parasite, Trypanosoma brucei, can acquire lipids from its
environment, recent reports have shown that it is also capable of de novo synthesis of all …

Phosphatidylethanolamine (PE) and phosphatidylcholine (PC) are the two major
constituents of eukaryotic cell membranes. In the protist Trypanosoma brucei, PE and PC …

Lipid metabolism in T rypanosoma brucei, the causative agent of African sleeping sickness,
differs from its human host in several fundamental ways. This has lead to the validation of a …

Trypanosoma brucei use microsomal elongases for de novo synthesis of most of its fatty
acids. In addition, this parasite utilizes an essential mitochondrial type II synthase for …

Sphingosine-1-phosphate is a signaling molecule involved in the control of cell migration,
differentiation, survival and other physiological processes. This sphingolipid metabolite can …

Mammalian phosphatidic acid phosphatases, also called lipins, show high amino acid
sequence identity to Saccharomyces cerevisiae Pah1p and catalyze the dephosphorylation …

PI (phosphatidylinositol) is a ubiquitous eukaryotic phospholipid which serves as a
precursor for messenger molecules and GPI (glycosylphosphatidylinositol) anchors. PI is …

Toxoplasma gondii is a highly prevalent obligate intracellular parasite of the phylum
Apicomplexa, which also includes other parasites of clinical and/or veterinary importance …