The physiological responses to estrogen hormones are mediated within specific tissues by
at least two distinct receptors, ERα and ERβ. Several natural and synthetic molecules show …

Eight isoflavones derivatives, with isoprenyl and/or 7-methoxy substitution, isolated from
Erythrina poeppigiana (Fabaceae) have been investigated for their estrogenic properties in …

Equol is a metabolite produced in vivo from the soy phytoestrogen daidzein by the action of
gut microflora. It is known to be estrogenic, so human exposure to equol could have …

Phytoestrogens are natural endocrine disruptors that interfere with estrogenic pathways.
They insert directly within the hormone-binding domain of ERα and β, with a preference for …

In a search for new ligands selective for the estrogen receptor beta (ERβ), we prepared a
series of non-steroidal compounds having an isocoumarin core structure. An interesting …

Plant-derived estrogen-like compounds, so called phytoestrogens, are given much attention
due to their potential therapeutic use. In our previous work the ethylacetate extract of …

In mammals, the effects of estrogen are mainly mediated by two different estrogen receptors,
ERα and ERβ. These proteins are members of the nuclear receptor family, characterized by …

Natural isoflavones have demonstrated numerous pharmacological activities in breast
cancer cells, including antiproliferative activities and binding affinities for estrogen receptors …

Aframomum melegueta is a spice widely used in African folk medicine. The chloroform
soluble fraction of A. melegueta seeds yielded four new diarylheptanoids named …

Isoflavones are diphenolic compounds found in most plants and in physiologically relevant
concentrations in legumes. Their chemical structure enables them to bind weakly to …