The dorsal column pathway consists of direct projections from primary afferents and of
ascending fibers of the post-synaptic dorsal column (PSDC) cells. This pathway mediates …

It has been proposed that death of inhibitory interneurons in the dorsal horn contributes to
the neuropathic pain that follows partial nerve injury. In this study, we have used two …

Neurons in the superficial laminae of the dorsal horn are dominated by input from peripheral
nociceptors. Following peripheral nerve injury, low threshold mechanoreceptive Aβ‐fibers …

The spinothalamic tract (STT) has been classically viewed as the major ascending pathway
for pain transmission while the dorsal column (DC) was thought to be involved primarily in …

Neuropathic pain is frequently characterized by spontaneous pain (ie, pain at rest) and, in
some cases, by cold-and touch-induced allodynia. Mechanisms underlying the chronicity of …

Chronic pain after nerve injury is often accompanied by hypersensitivity to mechanical
stimuli, yet whether this reflects altered input, altered processing, or both remains unclear …

This study was conducted to ascertain the possible expression of Fos-like immunoreactivity
(Fos-LI) in the postsynaptic dorsal column (PSDC) neurons in response to noxious …

Pain is a protective signal. It warns us of an impending or established injury (nociceptive
pain) and tells us that the integrity of our tissues is at risk, which could threaten our survival …

The neurophysiological literature on nociceptive neurons with ascending projections from
the spinal cord has been riven for almost 40years by a dogmatic controversy: many …

Peripheral nerve injury produces signs of neuropathic pain including tactile allodynia and
thermal hyperalgesia, sensory modalities which may be associated with different neuronal …