The skin epidermis and appendages undergo ongoing renewal throughout life. Stem cells
residing in the epidermis and hair follicles are pivotal for sustaining skin homeostasis. The …

Type XVII collagen (COL 17) is a transmembranous protein that is mainly expressed in the
epidermal basal keratinocytes. Epidermal‐dermal attachment requires COL 17 expression …

Abstract Collagen 17A1 (COL17A1) is a transmembrane structural component of the
hemidesmosome that mediate adhesion of keratinocytes to the underlying membrane …

Skin regenerative capacity declines with age, but the underlying mechanisms are largely
unknown. Here we demonstrate a functional link between epidermal growth factor receptor …

Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement
membrane zone. COL17 deficiency results in premature hair aging phenotypes and in …

The skin epidermis and its array of appendages undergo ongoing renewal by a process
called homeostasis. Stem cells in the epidermis have a crucial role in maintaining tissue …

The extracellular matrix protein collagen VII is part of the microenvironment of stratified
epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 …

Transmembrane collagen XVII is traditionally viewed as an important hemidesmosomal
attachment component that promotes stable dermal-epidermal adhesion in the skin …

Fibroblasts produce collagens and other proteins that form the bulk of the extracellular
matrix (ECM) in connective tissues. Emerging data point to functional heterogeneity of …

Epithelial stem cells in the skin are specified during development and are governed by
epithelial–mesenchymal interactions to differentially adopt the cell fates that enable them to …