We have previously shown that extended‐access subjects exhibit heightened motivation for
cocaine in the runway model, as reflected by reduced number of retreats. This heightened …

Rats allowed extended access to cocaine self-administration develop a number of
symptoms of addiction, such as greater susceptibility to drug-induced relapse. Using the …

Rationale Rats develop preferences for places associated with the immediate rewarding
effects of cocaine and aversions for places paired with the drug's delayed negative effects …

The aim of the present study was to determine if pre-exposure to high doses of cocaine can
subsequently alter the rewarding effects of this drug. Adult male mice received a …

Alcohol has been reported to modulate the reinforcing and aversive properties of cocaine.
Given these effects, the present study examined whether this interaction could be extended …

The rewarding effect of cocaine as reflected by the development of conditioned place
preference was examined in C57BL/6J and 129/J mice. Cocaine was administered in a …

Previous studies have demonstrated that rats showing a strong locomotor response to a
novel environment have a greater locomotor response to psychostimulant drugs and more …

To explore the way in which drugs act to reinstate drug-seeking behavior, we studied drug-
induced reinstatement of a cocaine-induced conditioned place preference (CPP). In a series …

An unbiased place preference conditioning procedure was used to determine whether the
repeated administration of cocaine results in sensitization to its conditioned rewarding …

Although cocaine administration in humans includes euphoric and anxiogenic effects, the
latter are less well understood. Acute cocaine administration produces aversive effects …