The purpose of this study is to determine the role of melanin in the various steps of
progression of melanocytic neoplasia. To this aim, we perform a retrospective analysis on …

We present a new method for studying melanin in vivo based on diffuse reflectance
spectroscopy of human skin. We find that the optical absorption spectrum of in vivo melanin …

We present an in vivo study of the optical properties of common nevi, dysplastic nevi and
malignant melanoma skin lesions in human subjects. Reflectance spectra were measured …

Objective measurements of melanin can provide important information for differentiating
melanoma from benign pigmented lesions and in assessing pigmentary diseases. Herein …

As some of the most ubiquitous and biologically important natural pigments, melanins play
essential roles in the photoprotection of skin. Changes in melanin production could …

Malignant transformation of melanocytes is associated with changes in melanogenesis.
Therefore, fluorescence of melanin may be an informative indicator of this process. But the …

Melanoma diagnosis is clinically challenging: the accuracy of visual inspection by
dermatologists is highly variable and heavily weighted toward false positives. Even the …

Background The main chromophores of human skin are melanins and hemoglobins along
with carotenoids, bilirubin, and other compounds. In an effort to study the spectral signatures …

Background: Spectroscopic methods have been used to analyze in vivo melanin in the past
but the specific effect of melanin depth on autofluorescence and reflectance spectroscopy …

Background Human cutaneous malignant melanoma (CMM) is an aggressive cancer
showing a dramatic worldwide increase in incidence over the past few decades. The most …