Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: Protein N‐myristoyltransferase: A new approach to antifungal therapy
JA Sikorski, B Devadas, ME Zupec… - Peptide …, 1997 - Wiley Online Library
MyristoylCoA: protein N‐myristoyltransferase (NMT) catalyzes the cotranslational covalent
attachment of a rare cellular fatty acid, myristate, to the N‐terminal Gly residue of a variety of …
attachment of a rare cellular fatty acid, myristate, to the N‐terminal Gly residue of a variety of …
Novel Biologically Active Nonpeptidic Inhibitors of MyristoylCoA:Protein N-Myristoyltransferase
B Devadas, SK Freeman, CA McWherter… - Journal of medicinal …, 1998 - ACS Publications
A new class of biologically active nonpeptidic inhibitors of Candida albicans NMT has been
synthesized starting from the octapeptide ALYASKLS-NH2 (2). The synthetic strategy …
synthesized starting from the octapeptide ALYASKLS-NH2 (2). The synthetic strategy …
Conformationally Constrained [p-(ω-Aminoalkyl)phenacetyl]-l-seryl-l-lysyl Dipeptide Amides as Potent Peptidomimetic Inhibitors of Candida albicans and Human Myristoyl …
SR Nagarajan, B Devadas, ME Zupec… - Journal of medicinal …, 1997 - ACS Publications
MyristoylCoA: protein N-myristoyltransferase (NMT) covalently attaches the 14-carbon
saturated fatty acid myristate, via an amide bond, to the N-terminal glycine residues of a …
saturated fatty acid myristate, via an amide bond, to the N-terminal glycine residues of a …
Design and syntheses of potent and selective dipeptide inhibitors of Candida albicans myristoyl-CoA: protein N-myristoyltransferase
B Devadas, ME Zupec, SK Freeman… - Journal of medicinal …, 1995 - ACS Publications
Myristoyl-CoA: protein N-myristoyltransferase (NMT; EC 2.1. 3.97), is a monomeric enzyme1-
2 which transfers the rare cellular fatty acid myristate from myristoylCoA to the IV-terminal …
2 which transfers the rare cellular fatty acid myristate from myristoylCoA to the IV-terminal …
Design and Synthesis of Novel Imidazole-Substituted Dipeptide Amides as Potent and Selective Inhibitors of Candida albicans MyristoylCoA:Protein N …
B Devadas, SK Freeman, ME Zupec… - Journal of medicinal …, 1997 - ACS Publications
A new class of antifungal agents has been discovered which exert their activity by blockade
of myristoylCoA: protein N-myristoyltransferase (NMT; EC 2.1. 3.97). Genetic experiments …
of myristoylCoA: protein N-myristoyltransferase (NMT; EC 2.1. 3.97). Genetic experiments …
Replacements for lysine in L-seryl-L-lysyl dipeptide amide inhibitors of Candida albicans myristoyl-CoA: protein N-myristoyltransferase
DL Brown, B Devadas, HF Lu, S Nagarajan… - Bioorganic & Medicinal …, 1997 - Elsevier
A survey of potential cyclic and acyclic lysine replacements in known l-seryl-l-lysyl dipeptide
inhibitors of C. albicans NMT identified the thioether 16 and glycinamide 18 as …
inhibitors of C. albicans NMT identified the thioether 16 and glycinamide 18 as …
[PDF][PDF] Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors
S Sogabe, M Masubuchi, K Sakata, TA Fukami… - Chemistry & Biology, 2002 - cell.com
Myristoyl-CoA: protein N-myristoyltransferase (Nmt) is a monomeric enzyme that catalyzes
the transfer of the fatty acid myristate from myristoyl-CoA to the N-terminal glycine residue of …
the transfer of the fatty acid myristate from myristoyl-CoA to the N-terminal glycine residue of …
[HTML][HTML] Scanning alanine mutagenesis and de-peptidization of a Candida albicans myristoyl-CoA: ProteinN-myristoyltransferase octapeptide substrate reveals three …
CA McWherter, WJ Rocque, ME Zupec… - Journal of Biological …, 1997 - ASBMB
Candida albicans produces a single myristoyl-CoA: protein N-myristoyltransferase (Nmt) that
is essential for its viability. An ADP-ribosylation factor (Arf) is included among the few cellular …
is essential for its viability. An ADP-ribosylation factor (Arf) is included among the few cellular …
A feature based pharmacophore for Candida albicans MyristoylCoA: protein N-myristoyltransferase inhibitors
RG Karki, VM Kulkarni - European journal of medicinal chemistry, 2001 - Elsevier
A three-dimensional pharmacophore model has been generated for Candida albicans
MyristoylCoA: protein N-myristoyltransferase (NMT) inhibitors, using the software program …
MyristoylCoA: protein N-myristoyltransferase (NMT) inhibitors, using the software program …
Antifungals targeted to protein modification: focus on protein N-myristoyltransferase
NH Georgopapadakou - Expert opinion on investigational drugs, 2002 - Taylor & Francis
Invasive fungal infections have increased dramatically in recent years to become important
causes of morbidity and mortality in hospitalised patients. Currently available antifungal …
causes of morbidity and mortality in hospitalised patients. Currently available antifungal …