Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT1B/D agonist

EA Kaiser, A Kuburas, A Recober… - Journal of …, 2012 - Soc Neuroscience
The neuropeptide calcitonin gene-related peptide (CGRP) plays a critical role in the
pathophysiology of migraine. We have focused on the role of CGRP in photophobia, which …

Induction of multiple photophobic behaviors in a transgenic mouse sensitized to CGRP

A Recober, EA Kaiser, A Kuburas, AF Russo - Neuropharmacology, 2010 - Elsevier
Migraine is a complex neurological disorder with a significant impact on patients and
society. Clinical and preclinical studies have established the neuropeptide calcitonin gene …

Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine

A Recober, A Kuburas, Z Zhang… - Journal of …, 2009 - Soc Neuroscience
Migraine is a chronic neurological disorder characterized by recurrent episodes of severe
unilateral throbbing head pain and associated symptoms, such as photophobia. Our current …

Induction of migraine-like photophobic behavior in mice by both peripheral and central CGRP mechanisms

BN Mason, EA Kaiser, A Kuburas… - Journal of …, 2017 - Soc Neuroscience
The neuropeptide calcitonin gene-related peptide (CGRP) is a key player in migraine.
Although migraine can be treated using CGRP antagonists that act peripherally, the relevant …

[HTML][HTML] A potential preclinical migraine model: CGRP-sensitized mice

AF Russo, A Kuburas, EA Kaiser… - Molecular and …, 2009 - ncbi.nlm.nih.gov
The neuropeptide calcitonin gene-related peptide (CGRP) plays a key role in migraine.
However, a major challenge for studying CGRP actions is the lack of animal models for …

Stimulation of posterior thalamic nuclei induces photophobic behavior in mice

LP Sowers, M Wang, BJ Rea… - … : The Journal of …, 2020 - Wiley Online Library
Objective A hallmark of migraine is photophobia. In mice, photophobia‐like behavior is
induced by calcitonin gene‐related peptide (CGRP), a neuropeptide known to be a key …

[HTML][HTML] CGRP administration into the cerebellum evokes light aversion, tactile hypersensitivity, and nociceptive squint in mice

M Wang, TL Duong, BJ Rea, JS Waite… - Frontiers in Pain …, 2022 - frontiersin.org
The neuropeptide calcitonin gene-related peptide (CGRP) is a major player in migraine
pathophysiology. Previous preclinical studies demonstrated that intracerebroventricular …

CGRP as a neuropeptide in migraine: lessons from mice

AF Russo - British journal of clinical pharmacology, 2015 - Wiley Online Library
Migraine is a neurological disorder that is far more than just a bad headache. A hallmark of
migraine is altered sensory perception. A likely contributor to this altered perception is the …

Investigating migraine-like behavior using light aversion in mice

M Wang, BN Mason, LP Sowers, A Kuburas… - JoVE (Journal of …, 2021 - jove.com
Migraine is a complex neurological disorder characterized by headache and sensory
abnormalities, such as hypersensitivity to light, observed as photophobia. Whilst it is …

Vascular actions of peripheral CGRP in migraine-like photophobia in mice

BN Mason, AS Wattiez, LK Balcziak, A Kuburas… - …, 2020 - journals.sagepub.com
Background Calcitonin gene-related peptide is recognized as a key player in migraine, yet
the mechanisms and sites of calcitonin gene-related peptide action remain unknown. The …