Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating
enhanced pain states by releasing proinflammatory cytokines and other substances thought …

Activation of p38 mitogen‐activated protein kinase (p38) in spinal microglia is implicated in
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …

Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …

The pharmacological attenuation of glial activation represents a novel approach for
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …

Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic
central pain, which can be refractory to conventional treatment approaches. It has been …

Recent research has shown that microglial cells which are strongly activated in neuropathy
can influence development of allodynia and hyperalgesia. Here we demonstrated that …

Microglia, the intrinsic macrophages of the central nervous system, have previously been
shown to be activated in the spinal cord in several rat mononeuropathy models. Activation of …

Background: Clinical studies of osteoarthritis (OA) suggest central sensitization may
contribute to the chronic pain experienced. This preclinical study used the monosodium …

It has become clear that spinal cord glia (microglia and astrocytes) importantly contribute to
the creation of exaggerated pain responses. One model used to study this is peri-spinal …

There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …